Chronic total occlusion of coronary artery
Conditions
Interventions
Statin group:N/A
Combined lipid-lowering group of statin and PCSK9 inhibitor group:N/A
Sponsors
Fuwai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) De novo CTO lesions of the main epicardial coronary artery (including the left anterior descending branch, the left circumflex branch, and the right coronary artery); (2) Successfully opened the CTO lesion and implanted the stent in any way; (3) Coronary blood flow reached TIMI grade 3 after stent implantation; (4) Aged =18 years old.
Exclusion criteria
Exclusion criteria: (1) CTO-PCI was unsuccessful; (2) TIMI blood flow in the distal coronary artery after CTO-PCI < grade 3; (3) Bifurcation lesions implanted with double stents; (4) CTO-PCI lesions of bridge vessels; (5) In-stent occlusion lesions; (6) Left ventricular ejection fraction <40%; (7) Acute myocardial infarction; (8) Patients who cannot use statins and/or PCSK9 inhibitors; (9) Patients who cannot use antiplatelet drugs; (10) Currently receiving PCSK9 inhibitor therapy; (11) Inappropriate for OCT examination; (12) Familial hypercholesterolemia; (13) Type I diabetes; (14) Previous cerebral hemorrhage; (15) Malignant tumors undergoing treatment; (16) Breastfeeding/pregnant women or women of childbearing age who do not take effective contraceptive measures; (17) No informed consent was signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In-stent neointimal loading percentage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stenosis degree of maximum lumen area;In-stent restenosis;Blood lipids;Adverse event; | — |
Countries
China
Contacts
Public ContactZhang Hongliang
Fuwai Hospital
Outcome results
None listed