Depression
Conditions
Interventions
Probiotics:Lactobacillus plantarum GL-5, Lactobacillus plantarum LZU-J-TSL 6, and maltodextrin
Placebo:Maltodextrin
Sponsors
School of life science, Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with depression aged between 18 and 65 years, and with no serious adverse reactions to commonly used antidepressants (included according to the DSM-V diagnostic criteria and the actual diagnostic advice of clinicians).
Exclusion criteria
Exclusion criteria: 1.Patients with treatment-resistant depression 2.Female patients currently in pregnancy and lactation 3.Depressive patients with severe self-harm or suicidal tendencies 4.Patients with serious physical illness (including but not limited to patients with malignant tumors and infectious diseases) 5.Patients with other mental disorders, such as schizophrenia, bipolar disorder, and neurodegenerative diseases 6.Other specific populations considered unsuitable for inclusion in this study (e. g. patients with abnormal thyroid function)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale;Hamilton Anxiety Rating Scale;Gastrointestinal Symptom Rating Scale;Self-rating depression scale;Self-rating anxiety scale;Athens insomnia scale;Pittsburgh sleep quality index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum IL-1ß;Serum IL-6;Serum TNF-a;Serum cortisol;Serum 5-HT;Serum 5-HTP;Serum GABA;Serum LPS;Serum Zonulin;Serum I-FABP;Serum Claudin-5;Fecal microbial analysis;Serum metabolomics; | — |
Countries
China
Contacts
Public ContactZhang Chunjiang
Lanzhou University
Outcome results
None listed