Intestinal and mental disorders
Conditions
Interventions
intervention group:Take a portion of cheese yogurt one hour after lunch every day for 28 days
control group:As a blank control, no intervention measures will be given, and the consumption of any probiotics, prebiotics, and other fermented milk will be restricted throughout the entire experimen
Sponsors
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-44 year; 2.17.0=BMI=28.0; 3. The following conditions are met: (1) Poor sleep quality; (2)Anxiety and depression risk; (3) Intestinal sub health status; 4. Willing to take probiotics and cooperate with stool collection, questionnaire and physical examination.
Exclusion criteria
Exclusion criteria: 1. Those who have recently taken antibiotics, probiotics, prebiotics, or have long-term habits of taking other yogurt that affect the test results; 2. Those with organic diseases, such as heart disease, liver cirrhosis, etc.; 3. Those who have mental disorders; 4. Diagnosed by hospitals at or above the county level with chronic non-communicable diseases, such as hypertension, gout, diabetes, etc.; 5. Patients diagnosed by hospitals at or above the county level with allergic diseases such as drug allergy, food allergy, rhinitis, etc., or those with a history of allergic diseases; 6. Have a history of gastrointestinal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut Microbiota;Short-chain fatty acids;neurotransmitter;HPA axis hormone;CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;IL-10;IL-12;TNF-a;IL-1ß;Blood routine;Liver function and renal function; | — |
Countries
China
Contacts
Public ContactHe Fang
West China School of Public Health, Sichuan University
Outcome results
None listed