Clinical study of different hypoglycemic regimens in the treatment of patients with Newly-diagnosed type 2 diabetes

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076753

Enrollment

Unknown

Registered

2023-10-17

Start date

2023-10-22

Completion date

Unknown

Last updated

2023-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

A.Insulin intensive treatment group:A1 insulin pump or basic+meal insulin intensive treatment for 7 days, followed by premixed insulin or basic+oral hypoglycemic therapy for 4 weeks

A2 insulin pump or basic+meal insulin intensive treatment for 7 days, followed by oral hypoglycemic therapy

A3 insulin pump or basic+meal insulin intensive treatment for 4 weeks.

B. GLP-1RA group:Treatment with GLP-1RA daily or weekly formulations for 4 weeks

C. SLGT-2 inhibitor group:Treatment with SGLT-2 inhibitor oral medication for 4 weeks, combined with other oral hypoglycemic drugs if necessary

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Clinically diagnosed as type 2 diabetes mellitus; 2.Over 18 years old; 3.People with newly-diagnosed type 2 diabetes or previously elevated blood sugar who have never been treated with medication; 4.BMI>20kg/m2; 5.Glycosylated hemoglobin>8.0%; 6.Patients voluntarily participateand sign informed consent before the trial.

Exclusion criteria

Exclusion criteria: 1. Type 1 diabetes, gestational diabetes or other special types of diabetes; 2. Uncorrected diabetes ketoacidosis or diabetes hyperosmolar state; 3. There is serious dysfunction of heart, liver, kidney and other organs; 4. There are acute stress conditions such as infection, gastrointestinal bleeding, cardiovascular and cerebrovascular diseases; 5. There are serious organic diseases of digestive system; 6. Pregnancy; 7. Mental disorders.

Design outcomes

Primary

Measure	Time frame
Fasting blood glucose;2 hours plasma glucose;fasting C peptide;glycosylated hemoglobin;	—

Secondary

Measure	Time frame
blood pressure;weight;waistline;Hip circumference;total cholesterol;triglyceride;low density lipoprotein;high density lipoprotein;hypoglycemia rate;	—

Countries

China

Contacts

Public ContactKun Lin

The First Affiliated Hospital of Shantou University School of Medicine

jornbar@126.com+86 135 5642 2916

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026