Choking response induced by sufentanil during the induction phase
Conditions
Interventions
C group:Normal saline 5ml
A1 group:esketamine 0.05mg/kg
A2 group:esketamine 0.10mg/kg
A3 group:esketamine 0.15mg/kg
Sponsors
Lishui People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who had selected thyroid surgery; 2. Aged 18-65 years; 3. American Society of Anesthesiologists (ASA) Grade I ~ II; 4. Cardiac function grade I ~ II.
Exclusion criteria
Exclusion criteria: 1. Smoking history; 2. BMI is greater than 28; 3. Preoperative intracranial, intra-abdominal or intraocular pressure increased; 4. Severe respiratory diseases, such as asthma, chronic cough, lung infection; 5. History of serious nervous system and heart, lung, brain and kidney diseases (such as gastroesophageal reflux, uncontrolled hypertension, diabetes, heart disease); 6. Use cough drugs (such as ACE inhibitors) or antitussive drugs before operation; 7. Long-term drug dependence and psychotic patients; 8. Subjects with opioid allergy; 9. Severe liver function abnormality; 10. Subjects who were judged to have difficulty in respiratory tract management were rated as grade IV by modified Markov score; 11. Known or suspected to be allergic or contraindicated to various components of the study drug or other benzodiazepines, opioids, propofol, muscle relaxants, etc; 12. Those who have participated in any clinical trial as subjects within 3 months before enrollment; 13. Other conditions determined by the researcher to be unsuitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of cough;Sore throat after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Pulse oxygen saturation;Nausea and vomiting;postoperative agitation; | — |
Countries
China
Contacts
Public ContactXuqiaomin
Lishui People's Hospital
Outcome results
None listed