Study on the effect and neuroplasticity mechanism of Liqi Jieyu mixtura in the treatment of depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076746

Enrollment

Unknown

Registered

2023-10-17

Start date

2023-10-21

Completion date

Unknown

Last updated

2023-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Liqi Jieyu Mixtura group:take Liqi Jieyu Mixtura

Escitalopram group:take Escitalopram tablets

Liqi Jieyu Mixtura and Escitalopram group:take both Liqi Jieyu Mixtura and Escitalopram tablets

Control group:None

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Meet the diagnostic criteria for depression in the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (International Classification of Diseases, ICD-10); 2. Aged 20~ 50s ; 3. Hamilton Depression Scale -17 items, score =17 points; 4.Education level above primary school; 5. Sign the informed consent. Health control group: ? Normal mental examination ? Hamilton Depression Scale 17 items (HAMD-17) score = 7 points; ? The age range is between 20 and 50 years old, and in terms of age, gender, marriage, education, and social function variables, it is basically matched with the first-episode depression group Willing to participate in this study and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with combined physical diseases and organic brain diseases; 2. comorbidities with other mental disorders and sleep disorders; 3. Patients with severe depression or serious suicidal tendencies; 4. Pregnant and lactating women; 5.Patients who have used any antipsychotic drugs, mood stabilizers and sedative hypnotic drugs in the past 2 weeks, those who have used long-acting antipsychotic drugs in the past 1 month, and those who have received electroconvulsive therapy in the past 3 months. Healthy control group: ? severe physical diseases ? intellectual disability or mental retardation IQ<90); ? Pregnant women ? have a previous history of mental disorders or a family history of mental disorders; ? History of abuse of psychoactive substances.

Design outcomes

Primary

Measure	Time frame
HAMD (Hamilton Dession Rating Scale) score;HAMA (Hamilton Rating Scale Anxiety) score;TMS-MEP (Transcranial Magnetic Stimulation Motor Evoked Potentials);TMS-EEG (Transcranial Magnetic Stimulation Electroencephalogram);	—

Countries

China

Contacts

Public ContactTang Yafang

Ningbo Kangning Hospital

tyf345@163.com+86 135 8688 9037

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026