Postoperative cognitive dysfunction
Conditions
Interventions
deep anaesthesia group:Maintaining deep anaesthesia intraoperatively
Light anaesthesia group:Maintenance of intraoperative light anaesthesia
Sponsors
Lishui People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65 years<Age = 90 years (male and female are not limited); 2. ASA grade ? ~ ?; 3.18 kg/m2 = BMI = 30 kg/m2; 4.Respiratory rate should be = 10 and = 24 times/minute in the screening and baseline periods; SpO2 should be = 95% when aspirating air; SBP = 90 mmHg; DBP = 60 mmHg; heart rate = 60 and = 100 beats/minute; 5. Understand the procedures and methods of this study, participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications to general anesthesia; 2, have a history of benzodiazepine allergy, or long-term use of benzodiazepines; 3, accompanied by infectious heart diseases such as myocarditis or endocarditis, sepsis; 4, craniocerebral injury, possible intracranial hypertension, brain aneurysm, cerebrovascular accident history of disease; 5. Acute heart failure, unstable angina pectoris, myocardial infarction within 6 months before screening, resting ECG heart rate =50 beats/min, third degree atrioventricular block and other serious arrhythmias, and serious heart valve disease; 6, abnormal liver and kidney function (ALT or AST=2.5 times the upper limit of normal value, TBIL=1.5 times the upper limit of normal value), abnormal kidney function (BUN or Urea=1.5 times the upper limit of normal value, Cr> Upper limit of normal, or dialysis treatment within 28 days prior to surgery), or significantly abnormal coagulation function (PT/APTT/TT higher than the upper limit of normal), anemia or thrombocytopenia (Hb=90g/L, PLT=80×109/L); 7. Patients with unsatisfactory blood pressure control (SBP=160mmHg, and/or DBP= 100mmHg during the screening period); 8. Seated systolic blood pressure SBP=90mmHg during the screening period; 9. Diabetic subjects whose blood glucose was not satisfactorily controlled (fasting blood glucose =11.1mmol/L during screening, and/or random blood glucose = 13.6mmol /L); 10, a history of drug use and alcohol abuse within 2 years prior to the start of the screening period, alcohol abuse was defined as regular drinking of more than 14 times/week (1 time =150 ml wine or 360 ml beer or 45 ml spirits); 11. Subjects who are judged to have difficulty managing their respiratory tract have a modified Markov score of level IV; 12. Participants who have participated in any clinical trial as a subject within 3 months before enrollment; 13. Other conditions deemed unsuitable for inclusion by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium (POD) at 7 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delayed neurocognitive recovery (DNR) after surgery;Postoperative neurocognitive disorders;Incidence of postoperative nausea and vomiting;Incidence of intraoperative knowledge;Incidence of intraoperative amnesia; | — |
Countries
China
Contacts
Public ContactWujimin
Lishui People's Hospital
Outcome results
None listed