acute brain injury, acute circulatory failure
Conditions
Interventions
Test group:The experiment is divided into three stages, namely the standard passive leg lift test stage, the improved passive leg lift test stage, and the fluid replacement test stage. The order of th
Sponsors
the First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age greater than or equal to 18 years old Patients with acute brain injury (including traumatic brain injury, hemorrhagic stroke, ischemic stroke, aneurysmal subarachnoid hemorrhage) Patients with acute circulatory failure (mean arterial pressure =65mmHg and/or systolic blood pressure =90mmHg and/or hyperlactatemia =2mmol/L and/or vasoactive drugs are used to maintain blood pressure)
Exclusion criteria
Exclusion criteria: Acute brain herniation caused by severe brain injury Intracranial pressure greater than 22mmHg Cerebral perfusion pressure lower than 60mmHg Acoustic window of the brain (temporal window) is poorly transparent, unable to perform effective transcranial Doppler ultrasonography Abdominal hypertension (intra-abdominal pressure = 15mmHg) Acute right heart failure (transthoracic echocardiography shows that the right ventricle is enlarged (end-diastolic basal segment diameter = 4.1 cm, right ventricle/left ventricular end-diastolic diameter ratio = 0.7), right ventricular systolic function is reduced (tricuspid valve ring systolic displacement =1.6cm), with/without tricuspid regurgitation, pulmonary hypertension, dilated inferior vena cava) Lower extremity deep vein thrombosis Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiac index;end-tidal partial pressure of carbon dioxide;Sensitivity and specificity of diagnostic methods; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral blood flow velocity in M1 segment of middle cerebral artery;Brain regional oxygenation saturation in bilateral frontal lobes; | — |
Countries
China
Contacts
Public ContactTang Rui
The First Affiliated Hospital of USTC
Outcome results
None listed