immunothrombocytopenia
Conditions
Interventions
Integrative Medicine Group:Yangyiqing granule combined with western medicine hormone therapy program
Western medicine treatment group:Conventional western medicine hormone therapy program
Sponsors
No.1 Affiliated Hospital of Henan Uuniversity of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 16 Years
Inclusion criteria
Inclusion criteria: ( 1 ) Conform to the western medicine diagnostic criteria of ITP. ( 2 ) Clinical classification is persistent ITP, chronic ITP. ( 3 ) TCM syndrome differentiation belongs to yin deficiency and blood heat syndrome, ( or ) and blood stasis syndrome. ( 4 ) Age 1 ~ 16 years old. ( 5 ) The bleeding grade and the corresponding bleeding degree were 0-3. ( 6 ) PLT < 30 × 109 / L within 48 hours before enrollment, or accompanied by bleeding symptoms or signs. ( 7 ) Patients who discontinued glucocorticoids for more than 1 week and still met the above inclusion criteria of Chinese and Western medicine. ( 8 ) The person or the legal guardian of the subject agrees and has signed the informed consent.
Exclusion criteria
Exclusion criteria: ( 1 ) Those who are allergic to the test drug, or do not receive traditional Chinese medicine treatment, or have contraindications to the test drug. ( 2 ) Patients who had no response to previous hormone therapy. ( 3 ) There are cardiac insufficiency, liver and kidney function damage, coagulation dysfunction. ( 4 ) Combined with severe infection, DIC, sepsis, fever, peptic ulcer, etc. ( 5 ) Congenital immunodeficiency or other serious primary diseases. ( 6 ) Clinical subjects who are receiving other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet count value;bleeding symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total platelet response rate;Reaction rate of platelet in each period;duration of the reaction;The increase of platelet;Improvement of bleeding grade;Improvement of TCM symptoms;Hormone dosage ( annualized );recurrence rate; | — |
Countries
China
Contacts
Public ContactDing Ying
Henan University of Traditional Chinese Medicine School of Pediatrics,No.1 Affiliated Hospital of Henan University of Traditional Chinese Medicine
Outcome results
None listed