Effect of pretreatment with lidocaine and intravenous paracetamol on propofol injection pain

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076700

Enrollment

Unknown

Registered

2023-10-16

Start date

2023-11-01

Completion date

Unknown

Last updated

2023-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propofol injection pain

Interventions

Group paracetamol:Subjects will receive intravenous paracetamol 1000mg within 15 minutes when preparing for anesthesia.

Group lidocaine:During anesthesia induction, lidocaine 40mg and 1/4 induction dose of propofol (2mg/kg) are simultaneously administered.

Group saline:During anesthesia induction, saline 2 ml and 1/4 induction dose of propofol (2mg/kg) are simultaneously administered.

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1.Elective ambulatory surgery 2.Aged 18-50 years 3.American Society of Anesthesiologists physical status I-II

Exclusion criteria

Exclusion criteria: 1.Chronic pain 2.Impaired liver or kidney function 3.Who had a known allergy to paracetamol,propofol or lidocaine 4.Who had taken analgesics or sedatives drugs in the previous 24 hours

Design outcomes

Primary

Measure	Time frame
Pain will be graded using a four-point scale;	—

Secondary

Measure	Time frame
Postoperative pain score;	—

Countries

China

Contacts

Public ContactYang Xu

Shenzhen Maternal and Child Health Hospital

403188997@qq.com+86 189 4817 2216

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026