Post-operative Pulmonary Complications
Conditions
Interventions
Intervention group:EIT-guided pulmonary protected ventilation
Control group:Conventional pulmonary protective ventilation
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 90; 2. Elective laparoscopic radical rectectomy under general anesthesia; 3.ASA grade 2 to 3; 4. Operation time >=2h; 5. Patients athigh risk of postoperative pulmonary complications (ARISCAT score > 44).
Exclusion criteria
Exclusion criteria: 1. Unable to obtain informed consent to participate in the study; 2. Turn to open, emergency operation; 3. Comply with any of the following: (1) History of any lung and / or abdominal surgery, history of asthma or chronic obstructive pulmonary disease, acute lung injury or acute respiratory distress syndrome, which is expected to require long mechanical ventilation after surgery; (2) Persistent hemodynamic instability, intractable shock, and severe heart disease (defined as conforming to the New York Heart Association III or IV cardiac function, or acute coronary syndrome, or persistent ventricular tachycardia); (3) Patients with cerebral stroke within three months before surgery; (4) Renal insufficiency (SCr is more than 2 times the normal reference range of our hospital, and the urine volume is less than 0.5ml/(kg·h), and the glomerular filtration rate is less than 60ml/h or proteinuria); (5) Cirrhosis (Child B or C); (6) Recent immunosuppressive therapy (defined as the need for chemotherapy or radiotherapy) is less than two months from the last chemotherapy or radiotherapy; (7) Allergy to narcotic drugs, suspected or suspected malignant hyperthermia (family) history; (8) Pregnancy (excluded by laboratory examination); (9) Any or suspected neuromuscular disease; (10) The physician in charge thinks it is not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative ventilation index;Surgical Rating Scale, SRS;Plasma lung injury markers;Inflammatory factor;Duration of hospital stay;Postoperative pain;Postoperative nausea and vomiting;Pulmonary ventilation changes; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed