Sepsis
Conditions
Interventions
Experimental Group:Remimazolam besylate for injection
Positive Control Group:Midazolam
Sponsors
The first affiliated hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18–80 years old. 2. Meet criteria of Sepsis 3.0, diagnosed sepsis within 48 hours. 3. SOFA score plus 2. 4. Patients with mechanical ventilation require sedative treatment. 5. Clearly know the purpose and objective of this clinical study and voluntarily enrolled.
Exclusion criteria
Exclusion criteria: 1. Aged less than 18–80 years old. 2. Woman in gestation and lactation period. 3. Allergy to componen to Remimazolam besylate for injection. 4. Patients with autoimmune diseases or those who have been using immunosuppressants for a long time. 5. Individuals with a history of severe arrhythmia. 6. Any condition in which remidazolam besylate for injection or midazolam is not suitable for sedation treatment. 7. The next of kin of each patients refuse to participate in this clinical trial. 8. Other circumstance that identified by researchers that do not suitable for this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RASS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| CPOT Score;MAP; | — |
Countries
China
Contacts
Public ContactWu Haiying
The first affiliated hospital of Kunming Medical University
Outcome results
None listed