Postoperative Delirium (POD), Colorectal Cancer
Conditions
Interventions
control subjects:Inhalation of 50% nitrogen and 50% oxygen
experimental group:Inhalation of 50% xenon/50% oxygen
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 65-80 years; 2.Patients undergoing elective laparoscopic colon cancer surgery; 3.American Society of Anesthesiologists (ASA) physical status I-III; 4.Ability to read and understand study materials and provide written informed consent.Only those who meet the above four criteria can be included in this study.
Exclusion criteria
Exclusion criteria: 1. History of allergy to xenon or anesthetic agents used during the study; 2. A history of psychiatric disorders such as depression, anxiety, schizophrenia, or mood disorders; 3. MMSE scores indicative of significant cognitive impairments (education level above secondary level 6 hours; 11. Concurrent participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium as assessed by 3-Minute Diagnostic Interview for Confusion Assessment Method 3D-CAM); | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of POD assessed with Delirium Rating Scale-Revised-98 (DRS-R-98) and the Confusion Assessment Method-Severity (CAM-S);POD onset time;duration of POD episode;POD subtypes, which were assessed using "Richmond Agitation-Sedation Scale";pain levels at rest and during movement, which were assessed daily by Visual Analogue Scale;sleep quality, which was determined daily by "Pittsburgh Sleep Quality Index";intraoperative hemodynamic and respiratory parameters;liver and kidney function, serum C-reactive protein level within postoperative 3 days, non-delirium complications throughout the observed period, and hospitalization costs; | — |
Countries
China
Contacts
Public ContactJin Mu
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed