general anesthesia
Conditions
Interventions
AF1:afentanil 40ug/kg
AF2:afentanil 60ug/kg
AF3:afentanil 80ug/kg
Sponsors
General Hospital of the Northern War Zone of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: a) 65 years old = Age = 79years old ,regardless of gender; b) Patients scheduled for elective endotracheal intubation under general anesthesia; c) ASA grade ? ~ ?(coronary heart disease); d) BMI 18-30kg/m2; e) Voluntary signing of Informed Consent Form.
Exclusion criteria
Exclusion criteria: a) The estimated length of hospital stay is less than 48h; b) Body mass index (BMI) 30kg/ m2; c) Severe cardiopulmonary function impairment (such as moderate and severe valvular heart disease, ejection fraction <55%, severe hypertension grade III, various arrhythmias requiring pacemaker installation, acute myocardial infarction, severe heart failure, severe lung dysfunction, etc.); d) Patients with acute upper gastrointestinal bleeding, pyloric obstruction, gastric content retention, esophageal stenosis and dysphagia easily induced reflux aspiration; e) Patients who are allergic to related drugs, have a history of alcoholism and drug dependence; f) Taking sedative and analgesic drugs such as diazepam and opioids 24 hours before medication; g) craniocerebral injury, intracranial hypertension, cerebral aneurysm, cerebral infarction, cerebral hemorrhage h) There were obvious dehydration and electrolyte disturbance after prolonged fasting before surgery; i) Mallampati airway grade ? ~ ?, indicating patients with difficult airways; j) Other investigators believe that the patient is not suitable to participate in the experiment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure changes after administration;Heart rate;Systolic blood pressure;Diastolic blood pressure;Cardiac index;Stroke volume variation;Cardiac output;change in bispectral index value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Superior dose of afentanil for general anesthesia induction in elderly patients;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactYuGang Diao
General Hospital of the Northern War Zone of the Chinese People's Liberation Army
Outcome results
None listed