Painless gastrological endoscopy
Conditions
Interventions
Propofol group:0.1-0.2ug/kg sufentanil (Renfu Pharmaceutical) and 1-2mg/kg propofol (Sichuan Guorui Pharmaceutical) were given.
Esketamine 1 group:After giving 0.2mg/kg Esketam (jiangsu hengrui Pharmaceutical), 1-2mg/kg propofol (Sichuan Guorui Pharmaceutical) was given.
Esketamine 2 group:After giving 0.3mg/kg Esketam (jiangsu hengrui Pharmaceutical), 1-2mg/kg propofol (Sichuan Guorui Pharmaceutical) was given.
Esketamine 3 group:After giving 0.4mg/kg Esketam (jiangsu hengrui Pharmaceutical), 1-2mg/kg propofol (Sichuan Guorui Pharmaceutical) was given.
Sponsors
Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 65, regardless of sex, with ASA grade I-II, weighing between 45 and 70 kg, are planned to undergo painless gastrointestinal endoscopy.
Exclusion criteria
Exclusion criteria: Patients with acute upper respiratory tract infection, asthma attack, acute severe throat disease and abnormal liver function; Patients who are allergic to benzodiazepines, fluoroMasini, opioids, propofol, egg products or soybeans; Patients with adrenocortical insufficiency, porphyria or chronic corticosteroid therapy; Patients with airway difficulty and hemodynamic instability (systolic blood pressure [SBP] 180 mmHg, diastolic blood pressure [DBP]>110 mmHg, peripheral blood oxygen saturation [SpO2]<90% under air inhalation); Patients with a history of sleep apnea; Addiction to alcohol, opioids or sedatives and hypnotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Pulse oxygen saturation;Anesthesia onset time;Total amount of propofol added; | — |
Secondary
| Measure | Time frame |
|---|---|
| Awakening event;PADSS grade; | — |
Countries
China
Contacts
Public ContactYunqiang Wan
Affiliated Hospital of Southwest Medical University
Outcome results
None listed