alcohol dependence
Conditions
Interventions
Arousal/propranolol group:propranolol
Arousal/placebo group:placebo
Non-arousal / propranolol group:propranolol
Non-arousal/placebo group:placebo
Arousal / 6 hours / propranolol group:propranolol
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) Subjects met the Diagnostic and Statistical Manual of Mental Disorder-5 (DSM-5) diagnostic criteria for alcohol use disorders; (2) Male; (3) Age 18-50 years old; (4) Junior high school education or above; (5) No history of abuse of other psychoactive substances (other than tobacco); (6) Right-handedness; (7) Alcohol Use Disorders Identification Test (AUDIT) score >15.
Exclusion criteria
Exclusion criteria: Exclusion criteria: ? Patients with neurological and mental diseases and bronchial asthma, cardiogenic shock, heart block (degree ? to III atrioventricular block), severe heart failure, sinus bradycardia and other cardiovascular diseases, brain, liver, kidney and other organic diseases; ? Patients with cardiac pacemakers, nerve stimulators, artificial metal heart valves, etc.; Those with aneurysm clips (except non-paramagnetic alloys); Persons with metal foreign bodies in the eye, inner ear implants, metal prostheses, metal prostheses, metal joints, and ferromagnetic foreign bodies in the body; Patients with non-removable metal foreign bodies (metal implants, dentures), insulin pumps, etc.; Patients with claustrophobia and other MRI contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| craving;Blood Pressure and Heart rate; | — |
Countries
China
Contacts
Public Contactxuyahui
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed