pulmonary complications
Conditions
Interventions
Intervention group: 100ml of 20% albumin was injected from induction of anesthesia to skin incision
Placebo control group:100ml of 0.9% Nacl was injected from induction of anesthesia to skin incision
Sponsors
Wuhan Union Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 120 Years
Inclusion criteria
Inclusion criteria: ?=65 years old; ?Patients undergoing the following primary cardiac surgery alone or in combination with cardiopulmonary bypass: coronary artery bypass grafting (CABG), valve repair or replacement, and aortic surgery; ? Preoperative albumin was 30-40g/L; ? Soliciting opinions from patients or their families, agreeing to participate in this trial, and signing an informed consent form.
Exclusion criteria
Exclusion criteria: ?A history of allergic reaction to albumin; ? Preoperative extensive positive inotropic drugs, intra-aortic balloon pump, extracorporeal membrane oxygenation or ventricular assist device support; ?Patients with preoperative renal insufficiency (serum creatinine concentration = 1.5 mg/dl before surgery) or patients requiring dialysis due to renal failure; ? Left ventricular ejection fraction = 40%; ?Mechanical ventilation was performed 7 days before surgery; ? Emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of postoperative pulmonary complications;The incidence of postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of invasive mechanical ventilation after surgery;Incidence of acute kidney injury after surgery;cardiac and vascular complications after surgery;Length of postoperative ICU stay;Length of postoperative stay;postoperative all-cause mortality; | — |
Countries
China
Contacts
Public ContactQingping Wu
Wuhan Union Hospital
Outcome results
None listed