Depression
Conditions
Interventions
Intervention group:During surgery, esketamine (0.4 mg/kg, 0.8ml/kg of solution) will be infused intravenously for 40 minutes. The postoperative intravenous analgesic formula is sufentanil 100 ug with
Control group:During surgery, placebo (0.8ml/kg normal saline) will be infused intravenously for 40 minutes. The formula of postoperative intravenous analgesia is sufentanil 125 ug, with a total volum
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-85 years; 2. Undergo elective knee or hip replacement surgery; 3. ASA (American Society of Anesthesiologists) I-III; 4. Preoperative depressive status (GDS-15 score >= 6 points); 5. Agree to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Refused to participate in the study; 2. Emergency surgery of joint replacement due to fracture or other reasons; 3. Have been diagnosed with depression and receive antidepressant therapy, or have taken antidepressant medication within 1 month; 4. Preoperative obstructive sleep apnea; 5. Unable to communicate before operation due to coma, severe dementia, speech disorder or severe hearing disorder; 6. Patients with severe hypertension, sinus tachycardia, acute coronary syndrome and severe intracranial hypertension before surgery; 7. Patients with severe liver dysfunction (Child-Pugh C grade), abnormal renal function (preoperative dialysis) or expected survival <= 24 hours; 8. Preoperative symptoms of schizophrenia, bipolar disorder, epilepsy, myasthenia gravis; 9. Have been treated with ketamine/esketamine; 10. Allergic to ketamine/Esketamine; 11. Refuse to use postoperative patient-controlled analgesia; 12. Participating in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of depression within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression severity within 7 days after surgery;Opioid consumption within 7 days after surgery;Pain severity within 5 days after surgery; | — |
Countries
China
Contacts
Public ContactYawei Li
Peking University First Hospital
Outcome results
None listed