postmenopausal osteoporosis
Conditions
Interventions
Group of postmenopausal osteoporosis :None
Sponsors
Wangjing Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Postmenopausal women, 45 years old = age < 65 years old; Menopause more than 1 year. (2) The diagnostic criteria for PMOP are met. The diagnostic criteria for PMOP based on the bone density of the axial bone (lumbar 1-4, femoral neck or total hip) or the bone density of the distal 1/3 of the radius measured by DXA are T-value =-2.5. (3) It meets the standard of TCM syndrome differentiation of kidney-yang deficiency or liver-kidney Yin deficiency syndrome. (4) Voluntarily participate in this clinical study and sign the informed consent. If only conditions (1) and (4) are met at the same time, and the T-value is =-1.0, you can be included in the healthy subjects. At the same time, patients who meet the conditions (1), (2), (3) and (4) are included in the ranks of PMOP patients.
Exclusion criteria
Exclusion criteria: (1) Patients with previous osteoporotic fractures. (2) Patients with secondary osteoporosis; Including metabolic diseases secondary to diabetes, thyroid disease, Cushing syndrome, etc. Chronic nephritis, malabsorption syndrome, chronic hepatitis and other systemic diseases. (3) Patients with serious organic and functional diseases such as malignant tumors, cardiovascular, cerebrovascular, liver, kidney and hematopoietic systems. (4) Patients who took drugs affecting bone metabolism within 3 months, such as bisphosphonates, glucocorticoids, calcitonin, anticonvulsants, heparin and other drugs. (5) Participants in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADCYAP1;CDH1;MUC1; | — |
Secondary
| Measure | Time frame |
|---|---|
| P1NP;ß-CTX;E2;BGP;ALP;BALP;TRACP;OPG;25(OH)D;PTH; | — |
Countries
China
Contacts
Public ContactWei Xu
Wangjing Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed