Vascular Cognitive Impairment
Conditions
Interventions
True acupuncture group:Subjects were required to receive 12 true acupuncture interventions within one and a half months.
Non-acupoint group:The non-meridian and non-acupoint parts near the acupoints in the true acupuncture group were selected for 12 times of shallow acupuncture.
Drug group:Within a month and a half to ' Aricept ' treatment, oral 1 pill a day.
Control Group:None
Sponsors
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients group: ( 1 ) Right-handed, age 50-85 years old, gender unlimited ; ( 2 ) Education level above primary school ( including primary school ) ; ( 3 ) Cognitive impairment is time-related to cerebrovascular events, or there is no cerebrovascular event, but the information processing speed and complex attention / frontal executive function are significantly impaired ; ( 4 ) According to the imaging diagnostic criteria of vascular cognitive impairment caused by cerebral small vessel disease ( VASCOG ), there were subcortical ischemic cerebrovascular lesions caused by cerebral small vessel disease in MRI and / or CT, including subcortical small infarction, high signal in white matter, vascular lacuna, perivascular space, microbleeds and brain atrophy ; ( 5 ) Neuropsychological scale assessment : MoCA score was between 10 and 26 points ; the total score of modified Hachinski ischemic scale ( MHIS ) was > 7, and the score of clinical dementia rating scale ( CDR ) was 0.5. ( 6 ) No contraindication of MRI scan; ( 7 ) Definite diagnosis of hypertension. Control group: (1) Right-handed, age range 50-85 years old, regardless of gender; (2) Normal cognitive function: MoCA score>26 points, Clinical Dementia Rating (CDF) score of 0, no history of mental illness such as depression; (5) I have not received any vascular dementia drugs, related physical therapy, or acupuncture treatment within the past month; (6) No life-threatening systemic diseases; (7) No contraindications for magnetic resonance imaging examination; (8) Understand the progress of this study and agree to sign an informed consent form.
Exclusion criteria
Exclusion criteria: Patients group: ( 1 ) Previous memory or other cognitive dysfunction, but there is no obvious ischemic lesion on the image ; ( 2 ) Cognitive dysfunction caused by trauma, tumor, infection, thyroid dysfunction, alcoholism, etc. ; ( 3 ) Severe visual acuity, hearing impairment and aphasia, affecting the examination or can not cooperate with the completion of the scale assessment, or can not keep still during MR scan ; ( 4 ) With depression, mental disorders and disturbance of consciousness ; ( 5 ) Severe circulatory, respiratory, urinary, digestive, hematopoietic system diseases ( such as unstable angina, uncontrolled asthma, active gastric bleeding, etc. ) and cancer ; ( 6 ) Have a history of traumatic brain injury or cerebral hemorrhage, massive cerebral infarction in the past 1 month ; ( 7 ) There are contraindications for MR examination ; ( 8 ) Received acupuncture treatment in the past 4 weeks ; ( 9 ) Can not complete the basic course of treatment, compliance may be poor ( that is, can not adhere to the treatment ) and difficult to follow up in the future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal cognitive assessment scale;Blood Oxygenation Level Dependent Imaging in Magnetic resonance imaging;Diffusion Tensor Imaging in Magnetic resonance imaging;Blood pressure variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative susceptibility mapping in Magnetic resonance imaging;Arterial Spin Labeling in Magnetic resonance imaging;MMSE, SDS, PSQI;Blood related indicators, including hypersensitive C-reactive protein (hs CRP), interleukin-6 (IL-6), serum ferritin, etc; | — |
Countries
China
Contacts
Public ContactWenli Tan
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed