depression
Conditions
Interventions
Gold Standard:Meet the first diagnostic criteria for depressive disorder in ICD-10 or DSM-5 or have not been taking antidepressants for at least two weeks
Index test:Methods: Platelet proteomics, transcriptome sequencing of mononuclear cells, bioinformatics analysis screened out biomarkers, and then machine learning verified the efficiency of candidate
Sponsors
Mental Health Center Affiliated to Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Study group inclusion criteria: A. meet the criteria for first diagnosis of depressive disorder in ICD-10 or DSM-5 or have not taken antidepressants for at least two weeks; B. Han Chinese residents, aged 18 to 60 years, male or female; C. primary school education or above; D. voluntary participation in this study. The control group was included in the criteria: A. Han Chinese residents, aged 18 to 60 years old, male or female; B. primary school education or above; C. voluntary participation in this study.
Exclusion criteria
Exclusion criteria: The exclusion criteria were the same in both groups: A. Consistent with DSM-IV axis I other diagnoses, such as schizophrenia, bipolar disorder, etc.; B. Serious physical diseases accompanied by poor control, such as coronary heart disease, abnormal thyroid function, etc.; C. History of craniocerebral trauma leading to loss of consciousness, or history of epilepsy; D. Any serious physical illness, treated with chronic medication; and/or history of substance abuse/dependenceE. pregnant or lactating women, or people planning to become pregnant (childbearing); F. recent history of fever, acute infection, infectious diseases, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| protein;HAMD Depression Scale;Accuracy ;Positive predicative value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity ;Specificity ; | — |
Countries
China
Contacts
Public ContactSun Lu
Mental Health Center Affiliated to Jiangnan University
Outcome results
None listed