Pediatric Brain tumors
Conditions
Interventions
Experimental group:PARP inhibitor targeted therapy
Control group:Conventional therapy
Sponsors
Department of Neurosurgery, Children’s Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: ? Children aged 0-18 years old with pediatric brain tumors confirmed by postoperative pathological diagnosis in a tertiary hospital in China with ?-H2AX positive were eligible for the study. ? Diagnostic imaging (preoperative and postoperative) must be included in the brain tumor clinical trial database of the Department of Neurosurgery, Children's Hospital of Fudan University for evaluation. ? Enrolled children and their guardians understood and were willing to accept follow-up. ? At the time of enrollment, the children were required to meet the requirements of 1 month or more after surgery, stable vital signs and general condition, clear consciousness, and autonomous swallowing function.
Exclusion criteria
Exclusion criteria: ? Children with unstable vital signs, endotracheal intubation, swallowing dysfunction, and no self-consciousness should be excluded from the experimental group. ? There is no evidence of recurrence or metastasis 5 years after operation. (3) patients with serious systemic diseases unrelated to tumors (such as severe infection, severe failure of cardiovascular system, respiratory system, liver or other organs), which make it impossible to take targeted drugs safely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gross tumor volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-Free Survival;Overall survival;Objective remission rate; | — |
Countries
China
Contacts
Public ContactLi Hao
Department of Neurosurgery, Children’s Hospital of Fudan University
Outcome results
None listed