Idiopathic nephrotic syndrome
Conditions
Interventions
Gold Standard:Patients with remission or recurrence of INS after treatment: recurrence of 24-hour urine protein>50mg/kg, or urine protein/creatinine>2000mg/kg. In children, recurrence is usually evalu
Index test:The levels of podocyte autoantibodies (Vinculin auto Ab, Serine argenine-rich slicing factor 9 auto-Ab, Proteasome subunit alpha type-1 auto-Ab, Aconate hydratase 2 auto-Ab, Peptidyl-propyl
Sponsors
The Children's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: Idiopathic nephrotic syndrome patients with complete remission of disease aged 2-18 years.
Exclusion criteria
Exclusion criteria: (1) Other kidney diseases, such as hereditary kidney disease, purpura nephritis, reflux nephropathy, diabetic nephropathy, amyloidosis, hypertensive nephropathy, etc. ; (2) Other autoimmune diseases, such as systemic lupus erythematosus, idiopathic arthritis, and ANCA-related vasculitis. ; (3) Subjects cannot observe or endure the necessary inspection procedures; (4) Patients with major mental illness or disturbance of consciousness, which researchers believe will have an impact on patient treatment and follow-up; (5) Patients who the researcher thought were not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vinculin auto-Ab;Serine arginine-rich splicing factor 9 auto-Ab;Proteasome subunit alpha type-1 auto-Ab;Aconitate hydratase 2 auto-Ab;Peptidyl-prolyl cis-trans isomerase D auto-Ab;Pcroxircdoxin 1 auto-Ab;F-actin-capping protein subunit beta auto-Ab;Recurrence after remission;Area under ROC curve;Accuracy;Sensitivity;Specificity;Positive predictive value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactQing Ye
The Children's Hospital, Zhejiang University School of Medicine
Outcome results
None listed