Idiopathic nephrotic syndrome
Conditions
Interventions
Gold Standard:The diagnostic criteria for idiopathic nephrotic syndrome are three highs and one low. The three highs are massive proteinuria, hyperlipidemia, and high edema, and the one low is hypopro
Index test:Detect the level of podocyte autoantibodies (Vinculin auto-Ab, Serine argenine-rich slicing factor 9 auto-Ab, Proteasome subunit alpha type-1 auto-Ab, Aconitiate hydratase 2 auto-Ab, Peptid
Sponsors
The Children's Hospital Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: New-onset idiopathic nephrotic syndrome patients aged 2-18 years.
Exclusion criteria
Exclusion criteria: (1)Other kidney diseases include hereditary kidney disease, purpura nephritis, reflux nephropathy, diabetic nephropathy, amyloidosis, and hypertensive nephropathy; (2)Suffering from systemic lupus erythematosus, idiopathic arthritis, ANCA-related vasculitis, and other autoimmune diseases; (3)Subjects cannot observe or endure the necessary inspection procedures; (4)Major mental illness or disturbance of consciousness, which researchers believe will have an impact on the treatment and follow-up of patients; (5)Patients were considered unsuitable for inclusion in the study by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vinculin auto-Ab;Serine arginine-rich splicing factor 9 auto-Ab;Proteasome subunit alpha type-1 auto-Ab;Aconitate hydratase 2 auto-Ab;Peptidyl-prolyl cis-trans isomerase D auto-Ab;Pcroxircdoxin 1 auto-Ab;F-actin-capping protein subunit beta auto-Ab;Accuracy;Sensitivity;Specificity;Positive predictive value;Negative predictive value;ROC curve; | — |
Countries
China
Contacts
Public ContactQing Ye
The Children's Hospital of Zhejiang University School of Medicine
Outcome results
None listed