Colorectal cancer
Conditions
Interventions
OFA group :Opioid free anethesia
OBA group:Traditional anethesia
Sponsors
Affiliated Cancer Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged from 18 to 65 years with ASAI-II colorectal cancer, regardless of gender or ethnicity; Elective/limited laparoscopic radical resection of colorectal cancer under general anesthesia with operation time > 2 hours; The patient and client agreed to participate in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients or their family members refused to participate in the study; 2.Pregnant or lactating women; 3.Allergy to one of the drugs used in this study or its excipients; 4.Emergency operation 5.Patients with BMI > 35 or obstructive sleep apnea 6.damage of liver and kidney function; 7.History of chronic pain, alcohol or drug abuse; 8.Central nervous system diseases (such as epilepsy, cerebral infarction or a history of cerebral hemorrhage) 9.Long-term use of ß-blockers, heart rate < 50 beats/min; 10.Cardiac insufficiency, unstable coronary artery disease, left ventricular ejection fraction (LVEF) < 40% 11.Diabetes mellitus, mental illness, long-term use of benzodiazepines or opioids 12. Unable to complete perioperative assessment due to dementia, speech disorder, hearing impairment, coma, terminal disease and other conditions; 13. Patients with heart atrioventricular block 14. Patients with contraindications to epidural puncture or patients who do not agree with puncture or puncture failure; 15. Patients with moderate or high risk of intravenous lidocaine use; 16. Attending doctors or researchers think that there are other reasons not to participate in this study [reasons need to be recorded]
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS pain score;QoR-15;Postoperative adverse reactions associated with opioid use;Anxiety and depression score;PSQI;Cortisol;Adrenalin;Noradrenaline;TNF-a;IL-6;IL-10;MAP;HR;MMP-7;TIMP-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS;Recovery period outcomes;The time required for initial postoperative analgesia;The number of additional controlled analgesia (PCA) within 48 hours after surgery;PACU residence time;Length of hospital stay after surgery;Bowel function recovery within 48 hours after surgery;Total amount of intravenous propofol used during operation; | — |
Countries
China
Contacts
Public ContactLinghui Pan
Affiliated Cancer Hospital of Guangxi Medical University
Outcome results
None listed