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Efficacy and safety of lung ablation in patients with lung cancer: a multi-omics study.

Efficacy and safety of lung ablation in patients with lung cancer: a multi-omics study.

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076517
Enrollment
Unknown
Registered
2023-10-11
Start date
2023-11-01
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Thermal ablation of lung cancer lesions:Microwave ablation was performed on lung cancer patients.

Sponsors

Beijing Chaoyang Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Continuous presence (follow-up time > 6 months) of pure ground glass nodules or partially solid ground glass nodules, 2) Patients with cancer risk factors, such as family history, smoking, air pollution, etc., 3) High risk factors in imaging, such as lesion maximum diameter =15 mm, burr sign, lobular sign, pleural depression, vacuole sign, vascular cluster sign, GGN increase in dynamic observation (observation time > 6 months), and an increase in the reality component, etc., 4) Because of poor cardiopulmonary function or old age, patients cannot tolerate surgical resection or refuse surgery for their own reasons, 5) The multidisciplinary team (MDT) is jointly discussed, and the final diagnosis and treatment advice is formulated based on the multidisciplinary team (MDT) and shared decision making (SDM) with the patient, 6) Understand and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1) Contraindications for bronchoscopy, including: Active massive hemoptysis; A recent myocardial infarction or an attack of unstable angina; Severe heart and lung dysfunction; Severe hypertension and arrhythmia; Uncorrectable bleeding tendency or severe coagulation dysfunction (such as platelets < 60×10^9/L), Uremia; Severe pulmonary hypertension; Severe superior vena cava obstruction syndrome; Intracranial hypertension; Acute cerebrovascular events; Aortic dissection or aortic aneurysm; Multiple pulmonary bulla; Extreme systemic failure; 2) Female patients who are breastfeeding or pregnant or preparing for pregnancy, 3) Patients with electromagnetic implantation devices in their bodies, 4) The subject is allergic to anesthetic; Or have a history of multiple severe allergies or hereditary allergies, 5) Participants who have participated in or are participating in drug clinical trials within 3 months before screening, or have participated in other medical device clinical trials within 30 days, 6) Other conditions deemed unsuitable for participation in this clinical trial by the investigator.

Design outcomes

Primary

MeasureTime frame
Proteomic;

Secondary

MeasureTime frame
Metabolomic;transcriptomics;

Countries

China

Contacts

Public ContactWangFeng

Beijing Chaoyang Hospital, Capital Medical University

zxl17805452756@163.com+86 139 1112 3259

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026