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Characterization of senescence-associated secretory phenotype and IFITM3 expression in the serum and their relationship with vascular calcification in patients on maintenance hemodialysis

Characterization of senescence-associated secretory phenotype and IFITM3 expression in the serum and their relationship with vascular calcification in patients on maintenance hemodialysis

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300076514
Enrollment
Unknown
Registered
2023-10-10
Start date
2023-08-07
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular calcification

Interventions

Healthy control group:N/A
Hemodialysis group:N/A

Sponsors

Zhong Da Hospital, Southeast University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Healthy control group: Age greater than or equal to 18 years;Signed informed consent; Previous CT plain chest, abdomen and pelvis at our hospital between June 1, 2023 and June 1, 2024; Hemodialysis patient group: regular hemodialysis population; Dialysis age = 6 months; Dialysis 3 times a week; During the period from June 1, 2023 to June 1, 2024, I underwent plain CT scans of the chest, abdomen, and pelvis at our hospital; Voluntary signing of informed consent form.

Exclusion criteria

Exclusion criteria: Healthy control group: suffering from mental illness; Patients who cannot cooperate due to other reasons; Hemodialysis patient group: pregnancy/lactation; Patients with other autoimmune diseases; Suffering from malignant tumors, liver cirrhosis, acute and chronic congestive heart failure (left ventricular ejection fraction<45%), congenital heart disease, rheumatic heart disease, acute inflammation, etc; Diseases that affect bone metabolism and calcium phosphate homeostasis, such as primary hyperparathyroidism; Patients with incomplete clinical data;

Design outcomes

Primary

MeasureTime frame
IFITM3;SASP;Calcification score;

Secondary

MeasureTime frame
Biological age;

Countries

China

Contacts

Public ContactZhao Yu

Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu

dndxzy@126.com+86 173 7227 5650

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026