Metabolic associated fatty liver disease
Conditions
Interventions
Gold Standard:The diagnostic results of MRI (MRI-PDFF)
Index test:1. The reliability of UDFF and auto-pSWE measurements
2. The diagnostic efficacy of UDFF in liver steatosis
3. The diagnostic efficacy of auto-pSWE in liver fibrosis
Sponsors
Zhongda Hospital Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the experimental group: 1. Adults aged 18 to 75; 2. There is MRI imaging evidence (PDFF>5%), and one of the following three conditions is combined: overweight/obesity, type 2 diabetes, and metabolic dysfunction. A. Overweight/obesity: Body mass index (BMI) = 24 kg/m ²; B. Type 2 diabetes: a. Patients newly diagnosed as diabetes: fasting blood glucose = 7.0 mmol/L, or blood glucose level at 2h after meal = 11.0 mmol/L or glycosylated hemoglobin (HbA1c) = 6.5%; b. Diabetes patients who have been diagnosed (whether or not they are taking medicine); C. Metabolic dysfunction: There are at least two risks of metabolic abnormalities: a. Waist circumference: male = 90cm or female = 80cm; b. Blood pressure = 130/85mmHg or receiving antihypertensive medication treatment; c. Blood triglycerides = 1.7mmol/L or receiving lipid-lowering medication treatment; d. Plasma high-density lipoprotein cholesterol: Male2mg/L; Inclusion criteria for the normal control group: Those with values less than 5% detected by MRI-PDFF and no significant abnormalities in liver related serum biochemical indicators.
Exclusion criteria
Exclusion criteria: Excluding patients with ascites, as shear waves cannot propagate through fluids; Excluding those with incomplete clinical data; Excluding those who cannot tolerate fasting for 6 hours and ultrasound examination; Exclude patients with severe cardiovascular, cerebrovascular, liver, kidney, immune system diseases, or serious illnesses who cannot cooperate; Excluding contraindications for magnetic resonance imaging examinations such as claustrophobia, metal implants, pacemakers, and artificial metal heart valves.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound-derived fat fraction;Automatic point shear wave elastic imaging technology;intraclass correlation coeficient,Coefficient of Variation;Sensitivity,specificity,ROC curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine, biochemistry, glycated hemoglobin, liver fibrosis, and fasting insulin levels;True positive, true negative, false positive, false negative; | — |
Countries
China
Contacts
Public ContactJia Li
Zhongda Hospital Affiliated to Southeast University
Outcome results
None listed