postoperative nausea and vomiting (PONV)
Conditions
Interventions
Group R:Induction with remazolam 0.3mg/kg (1min), sufentanil 0.3ug/kg (30s), cisatracurium 0.2mg/kg (15s)
maintenance with remazolam (0.1-0.3mg/kg/h), sevoflurance (1.5%), remifentanil (0.075~0.2µg/kg/min), and BIS 40~60.
Group P:Induction with propofol 2mg/kg (1min), sufentanil 0.3ug/kg (30s), cisatracurium 0.2mg/kg (15s)
maintenance with propofol (2-3.5ug/ml, TCI), sevoflurance (1.5%), remifentanil (0.075~0.2µg/kg/min), and BIS 40~60.
Sponsors
The First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects recieving elective gynecologic laparoscopy under general anesthesia; 2. ASA grade I~III; 3. Aged 18 to 65 years; 4. Sugery time >= 30 minutes; 5. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to Remimazolam or Propofol; 2. Schizophrenia or depression; 3. Emergency surgery; 4. Massive bleeding during the operation, and the shock time more than 30 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PONV within 24h afer sugery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of injection pain ;The incidence of hypotension (systolic BP < 90 mmHg or 25% decrease from baseline) within 10 minutes during inductiontion ;The incidence of remedial antiemesis;Nausea rating;patient satisfaction; | — |
Countries
China
Contacts
Public ContactMo Liqiu
The First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed