Osteoarthritis
Conditions
Interventions
Control group:Take placebo (1) 1g/qd+placebo (2) 0.25g/tid+placebo (3) 0.3g/qd orally for 12 weeks
Experimental group 1:Taking L-glutamine 1g/qd+placebo (2) 0.25g/tid+placebo (3) 0.3g/qd orally for 12 weeks
Experimental group 2:Taking 0.25g/tid of glucosamine+placebo (1) 1g/qd+placebo (3) 0.3g/qd orally for 12 weeks
Experimental group 3:Take 0.3g/qd of Celecoxib+placebo (1) 1g/qd+placebo (2) 0.25g/tid orally for 12 weeks
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to be the subject and sign the subject's informed consent form 2. Between the ages of 18 and 75, regardless of gender; 3. The study did not cover at least two types of oral therapy, namely, did not take glucosamine, L-glutamine or a combination of both, non steroidal anti-inflammatory and analgesic drugs, and other related treatment drugs two weeks before enrollment; 4. Early OA patients with clinical and/or imaging diagnosis of the hip/knee joint;
Exclusion criteria
Exclusion criteria: 1. Non randomized and/or non controlled; 2. The description of the treatment method is unclear; 3. Intervention combined with non-steroidal anti-inflammatory drugs; 4. Other osteoarthritis secondary to trauma, inflammation, joint instability, cumulative strain, or congenital diseases; 5. Patients with severe primary diseases of the heart, brain, liver, kidney, lungs, and hematopoietic system; 6. Individuals with allergic constitution, mental illness, pregnant or lactating women, unwilling to take contraceptive measures, late stage deformities, disabilities, or loss of labor; 7 Known history of alcohol addiction or drug abuse; 8. Patients with serious metabolic diseases and diabetes; 9. Osteoarthritis end-stage patients who require joint replacement; 10. Participants in other drug clinical trials within the first three months of enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities OA Index (WOMAC) subscale scores ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lequesne score;Imaging examination; | — |
Countries
China
Contacts
Public ContactWendan Cheng
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed