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Effects of modified cocktail formulation on analgesia and early functional rehabilitation after total hip arthroplasty: a prospective, double-blind, randomized controlled trial

Effects of modified cocktail formulation on analgesia and early functional rehabilitation after total hip arthroplasty: a prospective, double-blind, randomized controlled trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076435
Enrollment
Unknown
Registered
2023-10-09
Start date
2023-10-09
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the hip joint

Interventions

Group C:Group C received a traditional cocktail with only sodium bicarbonate
Group D:Group D received only traditional cocktail injections
Group A:Group A received a modified cocktail of injections
Group B:Group B received a traditional cocktail of injections containing only magnesium sulfate.

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients who underwent initial unilateral THA at our hospital for osteoarthritis of the hip joint, femoral head necrosis (Ficat stage IIIB or IV) or hip dysplasia (Crowe type I or II); (2) American Society of Anesthesiologists (ASA) classification I to III; (3) normal quadriceps muscle strength.

Exclusion criteria

Exclusion criteria: (1) hip ankylosis; (2) known hypersensitivity to medications used in this study; (3) opioid addiction or dependence; (4) alcohol addiction or dependence; (5) cognitive impairment; (6) psychiatric disorders; (7) recognized neuromuscular disorders; (8) previous hip surgery; (9) other neuropathy of the target side of the hip; and (10) inability to communicate verbally.

Design outcomes

Primary

MeasureTime frame
Time to first postoperative remedial analgesia;Postoperative dosage of remedial morphine hydrochloride;Visual analogue scale pain score;

Secondary

MeasureTime frame
Range of hip motion;Quadriceps strength;Daily walking distance;Incidence of postoperative complications;The duration of hospital stay;Inflammatory indicators;

Countries

China

Contacts

Public ContactKang Pengde

West China Hospital, Sichuan University

724339027@qq.com+86 183 9832 7222

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026