incomplete immune Reconstruction of AIDS
Conditions
Interventions
experimental group:ART+RGLSP
Control Group:ART+placebo
Sponsors
Xixi Hospital of Hangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-70, Gender Unlimited; 2.HIV infection is diagnosed in the laboratory and the diagnostic criteria follow the Chinese guidelines for the diagnosis and treatment of AIDS (2021 version) . 3.After ART, the viral load was below the low limit of detection ( 24 months, CD4 + T cell count was > 350/mL; 4. Good compliance, voluntary participation in the study, signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Recent heavy drinking (>3 times per week, >4 times per day) 2.Patients taking Sulfamethoxazole tablets 3.Serious Opportunistic infection, such as Pneumocystis pneumonia, tuberculosis, non-tuberculous mycobacterial infection, Cytomegalovirus infection, etc. 4.Complicated with severe heart, cerebrovascular disease, liver and kidney insufficiency, autoimmune disease, tumor and mental illness. 5.There are intelligence and language communication barriers, can not understand the content of the experiment and to cooperate with the experiment; 6.A woman who is pregnant, nursing, or planning a pregnancy. 7.People taking immunomodulators 8. Poor compliance, can not be required to take regular medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4+T cell count;CD8+T cell count;NK cell count;CD4+T/CD8+T; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolomics; | — |
Countries
China
Contacts
Public ContactJianhua Yu
Xixi Hospital of Hangzhou
Outcome results
None listed