COVID-19
Conditions
Interventions
Ozone treatment group:Drug therapy was carried out according to the guidelines for the diagnosis and treatment of COVID-19+ Ozone autologous blood therapy
Control group:Drug therapy was carried out according to the guidelines for the diagnosis and treatment of COVID-19
Sponsors
Shanghai East Hospital, Tongji University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 18-80, male and female; The diagnostic criteria for mild and medium novel coronavirus pneumonia in adults in the 10th Trial Edition of the 2023 Diagnosis and treatment plan are:1. Have clinical manifestations related to COVID-19 infection; 2. Have one or more of the following etiological and serological test results: (1) positive nucleic acid test of novel coronavirus; (2) positive antigen test of novel coronavirus; (3) Isolation and culture of the novel coronavirus are positive; (4) The level of novel coronavirus specific IgG antibody increased 4 times or more in the convalescent phase than in the acute phase. Clinical classification (1) Mild. The main manifestations were respiratory tract infection, such as dry throat, sore throat, cough, fever, etc. (2) medium-sized. Persistent high fever > 3 days or/and/or cough, shortness of breath, but RR 93% when breathing at rest. Imaging shows the characteristic manifestations of COVID-19 pneumonia; Patients who signed informed consent forms.
Exclusion criteria
Exclusion criteria: Massive blood loss, acute bleeding, anemia (Hb<90g/L); Severe coagulopathy or thrombocytopenia less than 50X10^9/L; Thalassemia, sickle cell anemia, glucose-6-phosphate dehydrogenase deficiency (patients with faba disease); Toxic diffuse goiter (Graves' disease); Severe unstable cardiovascular disease, acute myocardial infarction; Women who are pregnant or lactating or menstruating in women; Patients with psychiatric, neurological conditions or hypersensitivity; Continuous use of immunosuppressants or organ transplantation within the past 6 months; Investigator-assessed participants who felt that they were unable or unwilling to adhere to the protocol requirements. Intestinal obstruction, intestinal perforation, acute alcohol poisoning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory marker ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Viral nucleic acid testing time to conversion to negative;Chest CT; | — |
Countries
China
Contacts
Public ContactLiJun Liao
Shanghai East Hospital, Tongji University School of Medicine
Outcome results
None listed