AIDS
Conditions
Interventions
exposure group (Conversion to programs based on second-generation INSTIs or PIs):NA
control group (Continuous TDF/3TC/EFV):NA
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) HIV antibody positivity by ELISA and Western Blot, or HIV viral load = 5000 copies/mL; 2) Recent HIV viral load above 50 copies/mL and below 1000 copies/mL; 3) ART treatment with TDF/3TC/EFV regimen for more than 6 months; 4) Achieving viral suppression (HIV viral load <50 copies/mL) at least once after ART; 5) Age 18 or above (inclusive); 6) Volunteer to participate in the study, complete all follow-ups according to the requirements of the program and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients who refuse to provide ICFs; 2) Suffering from organic mental illness; 3) Pregnancy; 4) contradictory to treatment with second-generation INSTIs or PIs; 5) any other condition deemed by the investigator to be inappropriate for the study; 6) known history of resistance to tenofovir, lamivudine or efavirenz. ; 7) Plans to switch regimens after enrollment and before study endpoints.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIV viral load; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD4 cell;CD4+/CD8+; | — |
Countries
China
Contacts
Public ContactChen Jun
Shanghai Public Health Clinical Center
Outcome results
None listed