Non-small cell lung cancer
Conditions
Interventions
Experimental group (group A):Insert plant radiation
The control group (group B):IMRT
Sponsors
Southwest medical university affiliated hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed by pathological histology and cytology examination of non-small cell lung cancer, clinical stage III (according to the international association for the study of lung cancer and lung cancer TNM staging the American joint committee on cancer classification system version 8), whether surgical resection should be decided by a multidisciplinary team, at least contains a thoracic surgery doctors to assess; 2. Ages 18 to 80 years; 3. No radiation therapy contraindications, expected survival more than 6 months after radiotherapy. (PACIFIC 5:1 days life expectancy for at least 12 weeks) 4. ZPS score 0 to 2 points; 5. Pulmonary function test: forced expiratory volume in one second. FEV1 acuity 1.2 liters per second, or 50 or more 9 ? ? ? meter value; 6. No other previous history of pulmonary malignant tumor, is not made for systemic chemotherapy or radiotherapy chest lung cancer; 7. Women of childbearing age must be within 14 days before the group for a pregnancy test results were negative serum or urine, and voluntary in the observation period and at the end of the time within three months after giving the study drug use of appropriate methods of contraception; For men, should be surgical sterilization or agreed to at the end of the observation period and time within three months after giving the study drug using appropriate methods of contraception. . 8. Bone marrow function is normal, no blood transfusion (14 days, unused hematopoietic stimulating co-stimulating drug correct condition) meet the following criteria: > 4 x 109 / L WBC count, hemoglobin > 90 g/L (without blood transfusion), neutrophil counts acuity 2.0 x 109 / L, 100 x 109 / L or higher platelet count, serum creatinine and creatinine clearance normal p 60 ml/min, ALT, AST, < 2.5 times the normal reference value. Bilirubin within the normal range. 9. Normal coagulation function: 12 ~ 16 s PT and INR 0.8 ~ 1.5, APTT24 ~ 36 s, FIB2 ~ 4 g/L, 10. Without lidocaine anesthesia, such as drug allergy history; 11. Patients volunteered for and signed informed consent (or legal representative signed), good adherence, is expected to fit according to the plan calls for research. 12. Doppler ultrasound assessment: left ventricular ejection fraction (LVEF) of 50 or more
Exclusion criteria
Exclusion criteria: 1. Ever had any CTLA 4 resistance, resistance against PD 1 or PD - L1 antibody treatment; 2. The presence of test report confirmed driver mutations (such as EGFR, ALK mutations), can choose the corresponding targeted drugs for treatment; 3. The human immunodeficiency virus (HIV) infection or known to have acquired immune deficiency syndrome (AIDS), untreated active hepatitis (hepatitis b, is defined as the hepatitis b virus surface antigen (HBsAg), HBV - DNA test results positive p 500 IU/ml and abnormal liver function; Hepatitis c, defined as hepatitis c antibody (HCV - Ab] positive, HCV - RNA is higher than the detection limit of analysis methods and abnormal liver function) or combination of hepatitis b and hepatitis c infection; 4. Any active history of autoimmune disease or autoimmune diseases, such as interstitial pneumonia, uveitis, enteritis, hepatitis, the pituitary gland inflammation, vasculitis, myocarditis, nephritis, thyroid function, thyroid function reduce (after hormone replacement therapy can be incorporated into)); With childhood asthma has complete remission and adults without any intervention or vitiligo can be incorporated into, patients need bronchodilator for medical intervention is not included; 5.6) into the group of the first six months of moving/enous thromboembolism events, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis and pulmonary embolism, etc.; 6.7) significant clinical significance of history of cardiovascular disease, including but not limited to; (1) congestive heart failure (NYHA class > 2); (2) unstable angina; (3) signed within 3 months before the ICF happened myocardial infarction; (4) no need treatment or intervention of the chamber of arrhythmia or ventricular arrhythmia; 7. With uncontrolled neuropathy (level 2 or above) or psychiatric patients; 8. ? B stage T4 in clinical stage (extensive extrapulmonary invasion, such as the mediastinum, heart, great vessels, trachea, esophagus, vertebral body, juga, and malignant pleural and pericardial effusion) patients with exudative pleural effusion (even if the cytology negative patients). X line cannot detect the trace of pleural effusion can except; 9. The lesions located in the bronchial beam less than 2 cm; 10. Always have a history of invasive malignant tumor within the next three years (excluding the malignant melanoma skin cancer, breast, cervical, and oral carcinoma in situ); 11. Occurred within 30 days before the group of chronic obstructive pulmonary disease (copd) is aggravating requiring hospitalization or may not be able to tolerate the test solution treatment; 12. Two weeks before first treatment of severe infection (such as: intravenous drip antibiotic, antifungal and antiviral drugs), or for the first time during the screening/treatment before appear unexplained fever > 38.5 ° C; 13. Hepatic insufficiency lead to jaundice or blood coagulation function disorder; 14. Pregnancy and childbearing age women or men refuse to use appropriate contraception; 15. The known allergy to any experimental drug or its accessories; 16. Immune treatment within 4 weeks before a preventive vaccine or attenuated vaccine; 17. Researchers think that does not fit into the other.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival PFS;security; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival OS;ORR;DCR; | — |
Countries
China
Contacts
Public ContactWu Jingbo
Southwest medical university affiliated hospital zhong mountain campus
Outcome results
None listed