Labor Pain
Conditions
Interventions
Group1:nalbuphine 0.1mg/ml
Group2:nalbuphine 0.15mg/ml
Group3:nalbuphine 0.2mg/ml
Group4:nalbuphine 0.25mg/ml
Group5:nalbuphine 0.3mg/ml
Control group:None
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Parturients aged 18-40 years with healthy singleton pregnancies at term (=37 weeks gestational age), spontaneous onset of labor, latent phase of labor with cervical dilation of 2–5 cm, and painful contractions requiring labor epidural analgesia, without electrolyte disorders as well as infectious, immunologic, Endocrine system diseases.
Exclusion criteria
Exclusion criteria: parturients suffering from psychiatric and central nervous system disorders, liver disease, renal function abnormalities, cardiopulmonary function abnormalities, diabetes mellitus;severe obstetric comorbidities and complications such as pre-eclampsia and eclampsia, hyperemesis gravidarum, placenta previa, placenta previa; stillbirth; neonatal malformation; Parturients with contraindications to neuraxial anesthesia; abnormal coagulation function; recent use of cardiovascular drugs, sedative and analgesic drugs, hormonal drugs, anti-psychotic drugs and anticoagulant drugs; severe hypovolemia and hemodynamic instability, as well as refusing to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of cases of effective and ineffective labor analgesia in each group ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total amount of ropivacain consumption in each group;the total number of PCA demands ;Hemodynamic parameters of each group ;VAS score of each group;Ramsay score;Duration of first and second stage of labor;Method of delivery;Bromage score;Incidence of adverse reactions;Apgar score; | — |
Countries
China
Contacts
Public ContactLili Xu
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed