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Effect and brain mechanism of iTBS excitating left auxiliary motor area combined with low frequency rTMS inhibiting right M1 area to improve upper limb function in stroke patients with right hemiplegia

Effect and brain mechanism of iTBS excitating left auxiliary motor area combined with low frequency rTMS inhibiting right M1 area to improve upper limb function in stroke patients with right hemiplegia

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300076369
Enrollment
Unknown
Registered
2023-10-07
Start date
2023-10-10
Completion date
Unknown
Last updated
2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

one:True iTBS stimulated the left SMA and LF-rTMS stimulated the right M1
two:Pseudoitbs stimulated the left SMA and LF-rTMS stimulated the right M1

Sponsors

Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Left stroke patients with hemiplegia and aphasia confirmed by imaging examination (CT/MRI) 2. Age =35 years old and =75 years old, duration of disease 3 months to 1 year, onset of the first stroke 3. Vital signs were stable, and Brunnstrom's upper limb motor function could reach stage II-V 4. Right-handed, elementary school or above 5. No obvious cognitive impairment, non-linguistic cognitive assessment scale > 70 points 6. Understand and agree to participate in this study, and sign the informed consent

Exclusion criteria

Exclusion criteria: 1. Cerebrovascular disease is progressing 2. The lesions were located in bilateral cerebral hemispheres, cerebellum or brainstem 3. Previous epilepsy or family history of epilepsy, recent use of antiepileptic drugs 4. There are contraindications for transcranial magnetic stimulation and magnetic resonance examination, such as pacemakers and metal implants in the body 5. Severe heart, liver, kidney disease, etc., can not tolerate the test 6. Severe cognitive impairment, emotional or mental impairment, visual and hearing impairment

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Rating Scale upper limb;

Secondary

MeasureTime frame
magnetic resonance imaging;box and block test;Modified Barthel index;

Countries

China

Contacts

Public ContactShan Chunlei

Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

shanclhappy@163.com+86 138 1621 5058

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026