The impact of oxytocin induction on pain relief during labor in full-term premature rupture of membranes (PROM) patients.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076367

Enrollment

Unknown

Registered

2023-10-07

Start date

2023-10-10

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor analgesia

Interventions

premature rupture of membranes (PROM) group (P group):No intervention, only observe the analgesic effect during childbirth

Natural childbirth group (CON group):No intervention, only observe the analgesic effect during childbirth

premature rupture of membranes (PROM) group (P group):Measuring the EC50 of ropivacaine in full-term premature rupture of membranes (PROM) patients under the condition of 0.5µg/ml sufentanil

Natural childbirth group (CON group):Measuring the EC50 of ropivacaine in natural childbirth women under the condition of 0.5µg/ml sufentanil

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Primiparous women with full-term premature rupture of membranes (PROM) aged 20 to 40 who undergo oxytocin induction (control group consists of women with natural childbirth after membrane rupture), single pregnancies between 37 and 42 weeks. (2) Height between 155 to 175 cm. (3) No history of miscarriage. (4) Request for epidural anesthesia and cervical dilation =3 cm. (6) Classified as ASA (American Society of Anesthesiologists) grade I or II. (7) Normal coagulation function and platelet count. (8) NRS score =7.

Exclusion criteria

Exclusion criteria: (1) Cesarean section (2) Contraindications for epidural anesthesia (3) Induction before full term (4) Complications of heart, lung, kidney, and/or liver diseases (5) Complications of severe preeclampsia or malignant tumors (6) History of lower abdominal surgery (7) History of long-term sedative or painkiller use (8) History of mental illness (9) Other conditions not suitable for vaginal delivery.

Design outcomes

Primary

Measure	Time frame
NRS score;	—

Secondary

Measure	Time frame
Duration of labor;Hemodynamic;Apgar score;Cord blood gas analysis;Parturient women satisfaction;patient-controlled epiduralanalgesia (PCEA) press times and effective times;Duration of pain relief;additional dosage times;Maternity's overall NRS score for the delivery process;delivery outcome;	—

Countries

China

Contacts

Public ContactZhu Jiang

The Second Affiliated Hospital of Soochow University

zhujiangsz@126.com+86 139 6215 3438

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026