Disorders of consciousness
Conditions
Interventions
treatment group:1. Gene therapy virus
2. Respiratory inhalation drugs (dipentanone)
Sponsors
Shiyan Taihe Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis through medical history and CT scan of the head, and the patient is in a vegetative state or a persistent vegetative state for more than 3 months; 2. Aged 12-60 years; 3. Stable condition, no signs of hydrocephalus; assessed as MCS (Minimal Consciousness State) on the Coma Recovery Scale-Revised (CRS-R) for 6 revisions within 2 weeks; 4. Complete case data.
Exclusion criteria
Exclusion criteria: 1. Prior central nervous system diseases; 2. Unstable condition with coexisting infection; 3. Intolerance or non-compliance with cranial surgery treatment; 4. History of epilepsy; 5. Coexistence of brain atrophy, hydrocephalus, and presence of metallic implants or pacemakers; 6. Incomplete medical records.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| score of CRS-R ;score of brainstem auditory evoked potentials; | — |
Secondary
| Measure | Time frame |
|---|---|
| renal function;The mRNA levels of residual AAV viruses in the free plasma;Content of Dipentanone in Plasma; | — |
Countries
China
Contacts
Public ContactJie Luo
Shiyan Taihe Hospital
Outcome results
None listed