precocious puberty
Conditions
Interventions
Gold Standard:GnRH stimulation test
Index test:AMH in peripheral blood/capillary blood/urine
Sponsors
Shanghai Children's Medical Center
Eligibility
Sex/Gender
Female
Age
5 Years to 9 Years
Inclusion criteria
Inclusion criteria: ? GnRH dependent precocious puberty (CPP) group: 1) Female, age 5~9 years old; 2) Secondary sexual characteristics before 7.5 years of age or menarche before 10 years of age; 3) Bone age - age > 1 year; 4)GnRH stimulation test: LH peak =5IU/L and LH peak /FSH peak =0.6; 5) Sign informed consent. ? GnRH independent precocious puberty group: 1) Female, age 5~9 years old; 2) Secondary sexual characteristics before 7.5 years of age or menarche before 10 years of age; 3)GnRH stimulation test: LH peak < 5IU/L or LH peak /FSH peak < 0.6; 4) Sign informed consent.
Exclusion criteria
Exclusion criteria: Anyone who meets any of the following criteria should not participate in the study: 1) Patients with chronic diseases such as malignant tumors, tuberculosis, other endocrine diseases, acute/chronic infections, blood diseases, mental disorders, autoimmune diseases, and digestive disorders; 2) The patient had severe arrhythmia, congenital heart disease/cardiomyopathy, and cardiac insufficiency (NYHA grade ?/?); 3) The patient has significant liver disease (ALT or AST above 2 times the upper limit of normal); 4) The patient has significant renal impairment, defined as creatinine =110 µmol/L (or =1.3 mg/dL); 5) Patients take drugs that affect metabolism, such as glucocorticoids, thyroxine, growth hormone, etc.; 6) Known or suspected to cause serious discomfort to the test operation or related auxiliary examination; 7) Is participating in another clinical investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AMH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accuracy;Sensitivity;Specificity;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactXIUMIN WANG
Shanghai Children's Medical Center
Outcome results
None listed