Mild cognitive impairment in Parkinson's disease
Conditions
Interventions
Sponsors
Sichuan Bayi Rehabilitation Center (Sichuan Provincial Rehabilitation Hospital)
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion criteria for Parkinson's group:? Meet the diagnostic criteria of the UK Parkinson's Disease Brain Bank ? HY score = 2.5 ? Age 45-70 years old ? Not taking drugs to improve cognitive impairment before the fNIRS examination ? Agree to participate in this study and sign the informed consent form; ? The patients were in a good general condition, and their condition permitted to cooperate with the scores and examinations needed in the study.Diagnostic basis for PD-MCI Diagnostic criteria established by MDS 2012. (1)Inclusion criteria:? PD was diagnosed according to the clinical diagnostic criteria of the British Brain Unit.? On the premise that PD had been diagnosed, the patient complained, the informant or the doctor observed that there was a trend of gradual decline in cognitive function.? There was a suggestion of cognitive dysfunction in the above scale.? Cognitive decline did not significantly affect the functional independence of the patients with PD, but could present difficulties in dealing with complex problems. According to the Movement Disorder Society Working Group Level II criteria. The following conditions also need to be met:? Requires the presence of abnormal neuropsychological tests in at least two of the five cognitive domains, either suggesting abnormalities in both tests of the same cognitive domain or abnormalities in two different cognitive domains in a single test; ? Scores are below 1.5 standard deviations (SDs) from the mean; and ? Patients who do not meet the criteria of the PD-MCI are categorized as patients with PD with normal cognition ( PD with normal cognition, PD-NC).
Exclusion criteria
Exclusion criteria: (1) Parkinson's group exclusion criteria: ? patients with significant cognitive impairment, progression to PDD, affecting the ability of daily life ? patients with Parkinson's syndrome due to craniocerebral trauma, cerebrovascular disease, encephalitis, drugs or toxins, etc. ? patients with diagnosis of Parkinson's superimposed syndromes, such as multi-systemic atrophy, dementia with Lewy bodies, patients with cortical signs ? the presence of other systemic diseases affecting the functioning of the nervous system, the results of cognitive screening Patients ? with other obvious mental, neurological or systemic comorbidities, such as severe anxiety and depression, somatization disorder, etc. ? patients with serious liver and kidney diseases, cardiopulmonary insufficiency, malnutrition, malignant fluid, acute basal ganglia degeneration, etc. ? patients who cannot cooperate with the cognitive screening test due to serious loss of hearing and vision, dysgraphia, aphasia, etc. ? patients who have obvious abnormal findings on the brain imaging test, such as traumatic brain injury, stroke, brain tumor, cerebral hemorrhage, brain tumor, cerebral stagnation, brain tumor, brain tumor, brain tumor, and brain tumor. Cerebral hemorrhage, brain tumor, hydrocephalus, etc. ? MRI artifacts.Exclusion criteria for PD-MCI: ? Diagnosis of Parkinson's disease combined with dementia (PD with dementia, PD-D) based on the criteria of the MDS Task Force ? Presence of other causes of dementia, such as delirium, stroke, depression, metabolic disorders, adverse reactions to medications, or traumatic brain injury ? he presence of other symptoms of PD that significantly affect the assessment of cognitive function, such as dyskinesia, severe anxiety and depression, excessive somnolence, and psychosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in hemoglobin concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment,MoCA;Mini-Mental State Examination,MMSE; | — |
Countries
China
Contacts
Public ContactGong Yulai
Sichuan Bayi Rehabilitation Center (Sichuan Provincial Rehabilitation Hospital)
Outcome results
None listed