The role and mechanism of METTL3-mediated m6A methylation in regulating iron death of cardiomyocytes in myocardial injury in sepsis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300076332

Enrollment

Unknown

Registered

2023-10-04

Start date

2023-05-01

Completion date

Unknown

Last updated

2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Sepsis group:No

Control group:No

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) preoperative patients (aged 18-80 years), (2) patients with ASA grade I-III, (3) BMI<30kg/m2, and (4) voluntary informed consent signed by the patient and guardian

Exclusion criteria

Exclusion criteria: (1) myocarditis, hypertrophic cardiomyopathy and other myocardial related diseases, (2) BMI>30kg/m2

Design outcomes

Primary

Measure	Time frame
METTL3;	—

Secondary

Measure	Time frame
m6A methylase content;Iron death related factors;	—

Countries

China

Contacts

Public ContactXiao Feng

The Second Xiangya Hospital, Central South University

xiaofengcsu@csu.edu.cn+86 136 0743 0840

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026