Ropivacaine determination of 90% minimum Effective Concentration for ultrasound-guided modified pectoral nerve block in surgical analgesia for breast cancer :a double-blind, biased coin design up and down sequential trial

Ropivacaine determination of 90% minimum Effective Concentration for ultrasound-guided modified pectoral nerve block in surgical analgesia for breast cancer : a double-blind, biased coin design up and down sequential trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076311

Enrollment

Unknown

Registered

2023-09-30

Start date

2023-10-07

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Sequential group:Ultrasound-guided pectoral nerve block according to different ropivacaine concentrations allocated by baised coin design up and down method

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: First diagnosed breast cancer?elective operation of modified breast cancer, unilateral lesion, age 18-65 years, American Society of Anesthesiologists physical status I-II, informed consent to participate in the study, female

Exclusion criteria

Exclusion criteria: poor blood pressure contral(BP>160/100mmHg) ,Patients with block site infection, local anesthetic or anesthetic allergy, bleeding tendency, severe liver and kidney dysfunction, patients with severe cardiopulmonary diseases, psychiatric diseases, patients who refused to participate in the trial, and peripheral nerve diseases

Design outcomes

Primary

Measure	Time frame
Heart rate;Blood pressure;Sensory Block Evaluation;	—

Secondary

Measure	Time frame
Operation time;Surgical bleeding volume;Intraoperative opioid consumption;Time of stay in the postanesthesia care unit;time of the patient contral anesthesia;Number of times of rescue analgesia within 48 hours;time of discharge;	—

Countries

china

Contacts

Public ContactDuyu

Nanchong Central Hospital

542861618@qq.com+86 182 2739 0636

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026