hepatectomy
Conditions
Interventions
Control group:Administer physiological saline as a placebo, with a loading capacity of 0.5 hours before surgery. Intravenous infusion of 100 mL of physiological saline is maintained at a volume of 1 m
TXA I group:Tranexamic Acid, the loading dose of tranexamic acid was 10 mg/kg intravenous infusion 0.5h before operation, and the maintenance dose was 1 mg/(kg·h) intravenous pump until the end of ope
TXA II group:Tranexamic Acid, the loading dose of tranexamic acid was 1g intravenous infusion 0.5h before operation, and the maintenance dose was 10 mg/(kg·h) intravenous pump until the end of operati
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients of both sexes, aged 18-70 years, undergoing first elective laparoscopic hepatectomy; 2. ASA I-II; 3. Child-Pugh A/B; 4. No accompanying other major surgical procedures, such as intestinal, biliary and pancreatic resection.
Exclusion criteria
Exclusion criteria: 1. Obese patients (BMI > 32 kg/m²); 2. Contraindications to the use of tranexamic acid; 3. Patients with disease of heart head blood-vessel II level and above (hypertension, arrhythmia, cardiomyopathy, myocardial infarction, cerebral infarction); 4. Pregnant or lactating women; 5. Any unstable condition that may endanger the safety and compliance of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| activated partial thromboplastin time, APTT;prothrombin time, PT;fibrinogen, FIB;fibrinogen degradation products, FDPS;Blood loss;the rate of transfusion;hospitalization expenses; | — |
Secondary
| Measure | Time frame |
|---|---|
| thrombin time, TT;D-dimer;hospital stays; | — |
Countries
China
Contacts
Public ContactSi Yongyu
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed