Vascular stiffness
Conditions
Interventions
experimental group:0.5mg terazosin
control group:placebo
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male aged between 40 and 70 years; 2. PWV increased abnormally, exceeding the normal reference value (1400m/s) or considered as stiffness; 3. Without hard cardiovascular disease, including coronary heart disease,acute myocardial infarction, large artery hemangioma and stroke; 4. Normal hepatic and renal functions; 5. Without hematological disorders; 6. Meet the following criteria: a. self-care or basic self-care; b. good nutritional status; c. cognitive function is basically normal; d. optimistic and positive, self-satisfied; e. have certain health literacy and maintain a good lifestyle; f. active participation in family and social activities; g. good social adaptability; 7.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Have taken terazosin or tamsulosin or other a - adrenergic receptor blockers in the past three months; 2. Need to take type 5 phosphodiesterase inhibitors for erectile dysfunction or other diseases; 3. Need to take hypotensive drugs, hypoglycemic drugs or lipid lowering drugs due to abnormal blood pressure, blood glucose or blood lipid; 4. Individuals with angina pectoris, myocardial disease, valvular disease and coronary artery disease; 5. Patients with malignant tumor; 6. Unable to cooperate with treatment and follow-up; 7. Taking drugs that affect coagulation function and platelet function; 8. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brachial ankle pulse wave velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular events;Blood pressure;related gene sequencing results;flow mediated dilation;Cyclic molecular markers;Carotid intimal medial thickness, IMT; | — |
Countries
China
Contacts
Public ContactCuntai Zhang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed