Application and safety andysis of inhaled nitric oxide combined with prone position ventilation in patients with hypoxemia after cardiopulmonary bypass surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300076278

Enrollment

Unknown

Registered

2023-09-28

Start date

2023-10-01

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular diseases

Interventions

Case group:Inhaled nitric oxide combined with prone position ventilation group

Control group:Prone position ventilation group

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who undergo cardiopulmonary bypass surgery, with the type of surgery being aortic dissection or (and) valve surgery or (and) CABG; 2. Age>=18 years old; 3. Invasive mechanical ventilation and oxygenation index (PaO2/FiO2) <=200 mmHg; 4. Voluntarily participate in this study.

Exclusion criteria

Exclusion criteria: 1. Complicated by mlignant tumors or pregnant women, lactating women; 2. Patients with hemodynamically unstable (using high dose of norepinephrine, dobutamine to maintain the stability of hemodynamics) ; 3. Having severe organic diseases or comorbidities upon admission; 4. Patients with neurological diseases or organic brain injury, deep coma.

Design outcomes

Primary

Measure	Time frame
Reintubation rate;	—

Secondary

Measure	Time frame
Oxygenation index;Duration of mechanical ventilation;ICU stays;Pulmonary complications;Anxiety and depression;	—

Countries

China

Contacts

Public ContactLin Yanjuan

Fujian Medical University Union Hospital

fjxhyjl@163.com+86 591 8621 8336

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026