postoperative bladder catheter related discomfort
Conditions
Interventions
Group A :A single dose of esketamine 0.15 mg /kg in 2 ml normal saline is to inject intravenously 30 minites before the end of the surgery
Group B:A single dose of esketamine 0.25 mg /kg in 2 ml normal saline is to inject intravenously 30 minites before the end of the surgery
group C:2 ml normal saline is to inject intravenously 30 minites before the end of the surgery
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Participants undergoing selective ureteroscopic litholapaxy; 2. Aged 18-65 years old; 3. ASA 1~2; 4. Participants voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Delayed extubation or need to be sent to the ICU for continued monitoring after surgery; 2. Chronic pain or opioid abuse; 3. History of previous urinary tract obstruction requiring surgery; 4. Heart failure (ejection fraction 40); 15. Participnats with hypersensitivity to the active ingredient or all excipients of this product.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of catheter-related bladder discomfort above a moderate grade at 0h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of catheter-related bladder discomfort above a moderate grade at 1h/2h/6h postoperativel;The severity of catheter-related bladder discomfort at 0, 1, 2, and 6h postoperatively;The VAS score at 0, 1, 2, and 6h postoperatively;Sedation scores at 0, 1, 2, and 6 h postoperatively;Postoperative nausea and vomiting during the first 6h after surgery;The hallucination during the first 6h after surgery;Respiratory depression during the first 6h after surgery;Diplopia during the first 6h after surgery;The total sufentanil dosage used during surgery;The rescue tramadol dosage during the first 6h after surgery;The rescue metoclopramide dasage during the first 6h after surgery;Patient satisfaction at 6h postoperatively; | — |
Countries
China
Contacts
Public ContactWang Zhaoli
Peking University Shenzhen Hospital
Outcome results
None listed