endotracheal intubation responses in elderly patients
Conditions
Interventions
Experimental group:The first patient received Target Control Infusion (TCI) of remifentanil with a target concentration of 6ng/mL in the effector chamber. Subsequently, the patient was sequentially in
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients requiring general anesthesia and endotracheal intubation in ASA Class I to III, age = 65 years, surgery time = 2 hours, were eligible to participate in this study knowingly and voluntarily, and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Body mass index >30kg/m2 or <18.5kg/m2; (2) Patients diagnosed with sleep apnea syndrome; Patients who have a history of difficulty intubating, or who may have a difficult airway according to preoperative evaluation; (3) Patients undergoing double-cavity tracheal intubation under general anesthesia (4) patients with high risk of gastroesophageal reflux, aspiration or reflux; (5) Patients who are using painkillers for chronic pain, opioid addiction, or who are still using beta-blockers for cardiovascular disease on the day of surgery; (6) Patients who are using psychotropic drugs (valium, norepinephrine reuptake inhibitors, serotonin reuptake inhibitors); (7) Contraindication of remifentanil, such as: patients with known allergy to various components of this product or other fentanyl drugs, patients taking monoamine oxidase inhibitors, patients with myasthenia gravis and patients prone to respiratory depression, and patients with bronchial asthma and other diseases; (8) Entry tachycardia (HR= 100bpm) lasting for more than 5 minutes; (9) bradycardia (HR<40bpm); (10) Grade III hypertension (11) preoperatively known adrenal cortical insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Dosage of remifentani;Adverse reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index; | — |
Countries
China
Contacts
Public ContactLuo Tao
Peking University Shenzhen Hospital
Outcome results
None listed