Immune checkpoint inhibitor associated pneumonia
Conditions
Interventions
Gold Standard:Reference criteria: 1. History of immunotherapy (patient has received 1CIs treatment) 2. Imaging manifestations: New positive lung shadows (such as ground glass shadows, patchy consolida
Index test:High throughput sequencing technology (NGS) combined with alveolar lavage surgery
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign an informed consent form; 2. Age range from 18 to 75 years old, regardless of gender; 3. Immunosuppressive host; 4. Symptoms, signs, or imaging signs of pneumonia are visible, and empirical anti infection treatment is ineffective.
Exclusion criteria
Exclusion criteria: 1. Failure to complete microscopic examination and culture of alveolar lavage fluid or sputum; 2. The researcher believes that there are any individuals who are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bronchoalveolar lavage combined with pathogen metagenomic sequencing;Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Sputum/alveolar lavage fluid G/GM test;Chest CT;Characteristics of peripheral blood lymphocyte subpopulations;Cytokine assay; | — |
Countries
China
Contacts
Public ContactLiu Laiyu
Southern Medical University Southern Hospital
Outcome results
None listed