Tuberculous meningitis
Conditions
Interventions
Intervention:Add linezolid to standard antituberculousis regimen
Control group:Standard antituberculosis regimen
Sponsors
Shenzhen Third People's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as tuberculous meningitis who meet the diagnostic criteria of "2019 Chinese Guidelines for the Diagnosis and Treatment of Central Nervous System Tuberculosis". 2. above 0 years old; 3. Anti-tuberculosis treatment period should not exceed 1 week; 4. Patients under the age of 18 should be enrolled after signing the informed consent form (the guardian should give informed consent and sign for confirmation).
Exclusion criteria
Exclusion criteria: 1. AIDS. 2. Severe liver and kidney dysfunction (TBIL>2ULN, ALT or AST>5ULN, decompensated cirrhosis ccr<30ml/min). 3. Abnormal hemogram (WBC<2.0*10^9/L, N<0.5*10^9/L, HGB<60g/L, PLT<20*10^9/L) and bone marrow suppression confirmed by bone marrow puncture. 4. Seriously allergic or other contraindications to the anti-tuberculosis drugs or glucocorticoid. 5. Rifampicin-resistant or multidrug-resistant tuberculosis 6. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of SAE;Changes in GSC scores and BMRC grading at 2 and 4 weeks; | — |
Countries
China
Contacts
Public ContactMutong Fang
Shenzhen Third People's Hospital
Outcome results
None listed